发表的代表性论文:
1、Zhou X, Li T, Feng X, Hsiang E, Xiong Y, Guan KL ,
Lei QY. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem. J, 2011, In Press
2、Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and
Lei QY. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011, 42, 719-730 Feature article
3、Liu C, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY* (共通讯作者), and Kun-Liang Guan*. PP1 Cooperates with ASPP2 to dephosphorylate and activate TAZ. J. Biol. Chem. 2011 286(7):5558-66
4、Liu Y, Zha Z, Zhou X, Zhang H, Huang W, Zhao D, Li , Chan SW, Lim CJ, Hong WJ, Zhao S, Xiong Y,
Lei QY(共通讯作者) *, and Kun-Liang Guan* . The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFβ-TrCP E3 ligase. J. Biol. Chem. 2010 285: 37159-37169
5、Zhao,S-M., Xu,W., Jiang,W-Q., Yu,W., Lin,Y., Zhang,T-F., Yao,J.,Yang,P-Y., Li,H., Li,Y-X.,Shi,J., Qin,L-X., Lei,Q-Y., Xiong,Y., Guan,K-L. Protein acetylation plays an extensive role in regulating cellular metabolism. Science,2010,327:1000-1004
6、Zhang H , Liu C , Zha Z, Zhao B4, Yao J, Zhao S, Xiong Y, Lei, QY*(共通讯作者), and Guan K*. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 2009 284(20):13355-62
7、Zhao B, Lei QY*(共通讯作者), Guan KL*. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion Cell Biology, 2008, 20(6):638-46.
8、Lei QY*(共通讯作者), Zhang H, Zhao B, Zha Z, Pei X, Bai F, Zhao S, Xiong Y, Guan KL. TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway. Molecular and Cellular Biology,2008,28,2426-2436
9、Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Witte ON, Liu X, Wu H. NKX3.1 stabilizes p53, inhibits AKT activation and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell., 2006, 9, 367-378
10、Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell., 2003, 4(3), 209-21
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