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师资队伍

        雷群英, 复旦大学上海医学院教授,复旦生物医学研究院PI, 博士生导师。1993年获江西医学院预防医学专业学士学位, 1999年获苏州医学院生物化学与分子生物学专业硕士学位,2002年获复旦大学上海医学院生物化学与分子生物学专业博士学位。2002至2006年在美国加州大学洛杉矶分校作博士后研究,还分别到美国密执安大学、北卡大学Chapel Hill分校开展过短期的交流合作研究。2006年加入复旦大学,目前研究方向为Hippo-TAZ信号通路,肿瘤代谢,蛋白质翻译后修饰调控机制及其生理病理效应等。近6年发表18篇SCI 文章,以通讯或第一作者发表8篇。以项目负责人主持多项国家和地方项目包括国家自然科学基金、973子课题、上海市重点, 并入选上海市“浦江人才”,教育部“新世纪优秀人才”和上海市卫生系统“新百人计划”。


发表的代表性论文:

1、Zhou X, Li T, Feng X, Hsiang E, Xiong Y, Guan KL , Lei QY. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem. J, 2011, In Press

2、Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011, 42, 719-730 Feature article

3、Liu C, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY* (共通讯作者), and Kun-Liang Guan*. PP1 Cooperates with ASPP2 to dephosphorylate and activate TAZ. J. Biol. Chem. 2011 286(7):5558-66

4、Liu Y, Zha Z, Zhou X, Zhang H, Huang W, Zhao D, Li , Chan SW, Lim CJ, Hong WJ, Zhao S, Xiong Y, Lei QY(共通讯作者) *, and Kun-Liang Guan* . The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFβ-TrCP E3 ligase. J. Biol. Chem. 2010 285: 37159-37169

5、Zhao,S-M., Xu,W., Jiang,W-Q., Yu,W., Lin,Y., Zhang,T-F., Yao,J.,Yang,P-Y., Li,H., Li,Y-X.,Shi,J., Qin,L-X., Lei,Q-Y., Xiong,Y., Guan,K-L. Protein acetylation plays an extensive role in regulating cellular metabolism. Science,2010,327:1000-1004

6、Zhang H , Liu C , Zha Z, Zhao B4, Yao J, Zhao S, Xiong Y, Lei, QY*(共通讯作者), and Guan K*. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 2009 284(20):13355-62

7、Zhao B, Lei QY*(共通讯作者), Guan KL*. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion Cell Biology, 2008, 20(6):638-46.

8、Lei QY*(共通讯作者), Zhang H, Zhao B, Zha Z, Pei X, Bai F, Zhao S, Xiong Y, Guan KL. TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway. Molecular and Cellular Biology,2008,28,2426-2436

9、Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Witte ON, Liu X, Wu H. NKX3.1 stabilizes p53, inhibits AKT activation and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell., 2006, 9, 367-378

10、Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell., 2003, 4(3), 209-21

 


 

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