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师资队伍

    雷群英,教授,博士生导师。2002年获上海医科大学医学博士学位,之后在美国加州大学洛杉矶分校做博士后研究,2006年被复旦大学引进,国家杰出青年基金获得者,先后入选上海市科委"浦江人才"、教育部"新世纪优秀人才"、上海市卫生系统"优秀学科带头人"、上海市教委"曙光学者"和上海市优秀学术带头人。荣获明治生命科学奖杰出奖和上海市三八红旗手。主持973、国家自然科学基金、上海市重点课题等项目,发表SCI论文20余篇。

研究方向 :
1、肿瘤代谢
2、Hippo-TAZ信号通路

联系方式:
qunyinglei@gmail.com
Tel:021-54237935

代表性论文:(其中* 为通讯作者)

1、Zhao D, Zou S, Liu Y, Zhou X, Mo Y, Wang P, Xu Y, Dong B, Xiong Y*, Lei QY* and Guan KL*., Lysine-5 Acetylation Negatively Regulates Lactate Dehydrogenase A and Is Decreased in Pancreatic Cancer. Cancer Cell 2013, 23, 464-476

2、Huang W, Lv X, Liu C, Zha Z, Zhang H, Jiang Y, Xiong Y, Lei QY*, Guan KL*. The N-terminal phosphodegron targets TAZ/WWTR1 for SCFβ-TrCP dependent degradation in response to PI3K inhibition. J. Biol. Chem. 2012 287(31):26245-26253

3、Zhou X, Li T, Feng X, Hsiang E, Xiong Y, Guan KL , Lei QY*. Targeted polyubiquitylation of RASSF1C by the Mule and SCFβ-TrCP ligases in response to DNA damage. Biochem J. 2012 441(1):227-36.

4、Lv L, Li D, Zhao D, Lin R, Chu Y, Zhang H, Zha Z, Ying Liu, Li Z, Xu Y, Huang Y, Gang W, Xiong Y, Guan KL, and Lei QY*. Acetylation Targets the M2 Isoform of Pyruvate Kinase for Degradation through Chaperone-Mediated Autophagy and Promotes Tumor Growth. Molecular Cell. 2011, 42, 719-730 Feature article

5、Liu C, Lv X, Li T, Xu Y, Zhou X, Zhao S, Xiong Y, Lei QY*, and Kun-Liang Guan*. PP1 Cooperates with ASPP2 to dephosphorylate and activate TAZ. J. Biol. Chem. 2011 286(7):5558-66

6、Liu Y, Zha Z, Zhou X, Zhang H, Huang W, Zhao D, Li , Chan SW, Lim CJ, Hong WJ, Zhao S, Xiong Y, Lei QY*, and Kun-Liang Guan* . The Hippo tumor pathway promotes TAZ degradation by phosphorylating a phosphodegron and recruiting the SCFβ-TrCP E3 ligase. J. Biol. Chem. 2010 285: 37159-3716

7、Zhang H, Liu C, Zha Z, Zhao B4, Yao J, Zhao S, Xiong Y, Lei, QY*, and Guan K*. TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition. J. Biol. Chem. 2009 284(20):13355-62

8、Zhao B, Lei QY*, Guan KL*. The Hippo-YAP pathway: new connections between regulation of organ size and cancer. Current Opinion Cell Biology, 2008, 20(6):638-46.

9、Lei QY*, Zhang H, Zhao B, Zha Z, Pei X, Bai F, Zhao S, Xiong Y, Guan KL. TAZ Promotes Cell Proliferation and Epithelial-Mesenchymal Transition and Is Inhibited by the Hippo Pathway. Molecular and Cellular Biology,2008,28,2426-2436

10、Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, Witte ON, Liu X, Wu H. NKX3.1 stabilizes p53, inhibits AKT activation and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell., 2006, 9, 367-378

 


 

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